CWS Instructional Manual

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CellMate Wellness Systems Instructional Manual Table of Contents Preface Quote from "The Fabric of Reality" Dr. David Deutsch - Oxford University An Unprecedented Alliance - Direct Laboratory Services and CellMate Wellness Systems A. The CellMate Wellness Systems™ Report CM Blood Test Report Description Brief overview of what the Report provides Test Element Descriptions Description of the Components Panel/Subset Listings and Definitions Clinical Correlations List Drug Interactions List Validation of an Interpretive Reporting Systems Paper Explanation of the Protocol System B. Introduction to Human Toxicity Toxicity Factors Biological Aging Stress Management Xenobiotics Surgeon General's Report Standard American Diet USDA - National Food Consumption Survey USDA - Nutritional Survey NHANES-II Survey The Myth of the Good Diet Diet and Nutrition The Major Minerals - Calcium, Magnesium, Phosphorus, Zinc Antagonists - Calcium, Phosphorus, Magnesium, Zinc, Manganese, Copper, Iron, Potassium The Vitamins - A, C, E, B Vitamins, Carotenoids, Coenzyme Q10 Nutrition and Drug Nutrient Depletion Antibiotics - Prescription for cure or curse? Nutritional Education in Medical Training Basic tenets of allopathic medicine Pasteur vs Beauchamp New Tenets of Medicine Physiological Sequence of Disease Process Dental Toxicity Factors Oral Galvanism Corrosion - Dry and Wet Objective Symptoms Mercury toxicity Focal Infection Bowel Terrain Mouth Stomach Small Intestine Large Intestine Digestive Dysfunction Maldigestion Diseases associated with low gastric acidity Signs and Symptoms of low gastric acidity Pancreatic insufficiency Clinical problems associated with malabsorption Signs and symptoms of malabsorption Dysbiosis and "Leaky Gut Syndrome" Adrenal Insufficiency Allergies Concepts/models Barriers for Preservation of Self Symptoms Allergy Identification Types of hypersensitivity response - Types I, II, III, IV Allergy Intervention Detoxication and Detoxification Therapeutic Detoxification Liver Detoxication Phase I Phase II Detoxification Profile P-450 enzymes Phase II sulfation Phase II Glutathione conjugation Phase II Glycine conjugation Phase II Glucuronidation Detoxification Intervention Induced P-450 systems (Phase I) Inhibited P-450 systems (Phase I) Glutathione conjugation (Phase II) Sulfation (Phase II) Glucuronidation (Phase II) Glycine Conjugation (Phase II) Key Detox Support Detoxication - Summary of interventions C. Determining Nutrient Needs Aging Nutrition and Medical Care Standard American Diet Food Quality Shifts in US Food Practices Soft Drink Consumption The Food Pyramid US Population weight issues USDA Nutritional Survey RDA's Myth of the "Good Diet" Mineral variations in food Diet and Nutrition Nutrient Demand Variables Health Maintenance Dietary Recommendations Vitamins: What Should I Take Diet and Nutrition The Major Minerals - Calcium, Magnesium, Phosphorus, Zinc Antagonists - Calcium, Phosphorus, Magnesium, Zinc, Manganese, Copper, Iron, Potassium The Vitamins - A, C, E, B Vitamins, Carotenoids, Coenzyme Q10 Factors in Deficiency Vitamins Vitamin A/Carotenoids Vitamin C Vitamin E CHAOS Study Vitamin B B6, B12 and Intrinsic Factor, Folic Acid, Choline and Inositol Additional Supplement Suggestions Essential Fatty Acids, Taurine, Carnitine, N-Acetyl Cysteine, Lycopene Essential Fatty Acids Omega-3's - Fish Oil, Flax seed, Docosahexanoic acid (DHA) Nutrition Status and Drug Nutrient Depletion Assessment Confusion A Normal Blood Test Limitations of the Standard Interpretation D. Biological Assessment Biological Assessment - Adaptive Mechanisms and Nutrient Demand Variables Definitions Stages of Nutrient Depletion Dietary Insufficiency Diminished tissue reserves Decreased body fluid levels Decreased functional levels in tissues Decreased activity of nutrient dependent enzymes Functional change Clinical symptoms Anatomical signs Disease Biological Assessment - Functional Variations Assessment Value Distortion Nutrient Demand Variables A New Paradigm Biological Assessment - Determination Schemes Direct Element Reaction Testing (DERT) vs Inferential Determination Schemes (InDS) Statistical Analysis - DERT Statistical Analysis - InDS Biological Assessment - Laboratory Method Selection Plasma/Serum Erythrocytes Leukocytes Tissue Stores Biopsy Hair - Pluses and Minuses Specimen Options Urine Saliva Stool Bowel Terrain - Urine versus Stool E. Introduction to Testing Protocols Comprehensive Wellness Profiles, Amino Acids and Organic Acids Comprehensive Wellness Profiles Complete Blood Count (CBC) Differential Electrolytes Liver Panel Protein and Nitrogen Panel Lipid Profile Thyroid Panel Others Other available Why order this test? Limitations Amino Acid 40 Plasma Why this test? Special Metabolic Functions of Amino Acids Organic Acids in Urine Applications Functional deficiencies assessed So what is the proper sequence? Comprehensive Wellness Profile Plasma Amino Acids Urine Organic Acids Others Why this sequence? Why the Comprehensive Wellness Profile? Why the Amino Acid Plasma Test? Why the Organic Acid in Urine Test? The CellMate™ Report Why it is valuable and what it provides. Validity F. Basic Chemistry Assessment Pathology Markers versus Metabolic Screening Pathology Markers Hematology, Immune, Lipids, Enzymes and Hepatic function, Electrolytes, Nitrogen, Protein, Others Metabolic Screening Adrenal, Allergy, Antioxidant Status, Athletic Potential, Bone/Joint, Cardiac Markers, Cellular Distortion, Differential/Count, Electrolytes, GI Function, Hematology, Inflammatory Process, Kidney Function, Lipids, Liver, Nitrogen, Protein, Pulmonary Function, Ratios and Thyroid. Deficiency Indicators Priority of Imbalances Iron Status Assessment Common deficiency Gut absorption controlled Iron Overload Iron Components Essential Iron Storage Iron Transport Iron Iron Depletion Stage 1 Stage 2 Hemoglobin Hematocrit Hematocrit Limitations Red Cell Indices Mean Corpuscular Volume (MCV) Mean Corpuscular Hemoglobin Concentration (MCHC) Mean Corpuscular Hemoglobin (MCH) Differential Assessment Value Variations G. Botanicals Chemistry Correlations Alfalfa, Aloe Vera, Astragalus, Ashwagandha, Barberry, Bayberry, Black Cohosh, Catechin, Cat's Claw, Coleus Forskohilli, Cranberry, Dandelion, Echinacea, Fenugreek, Feverfew, Garlic, Ginger, Ginkgo Biloba, Goldenseal, Gugulipid, Hawthorn, Licorice Root, Silymarin, Stinging Nettle, Turmeric. H. Introduction to Amino Acids Functions Availability Adequacy Factors Protein Quality Demand Variables Non-Essentials Involvement in Metabolic Functions Enzyme systems Essential Amino Acids Neurotransmitter Metabolism Ammonia/Energy Metabolism Sulfur Metabolism Other Amino Acids Glucose Synthesis Tissue Protein Synthesis Urea Cycle Glutathione DNA/RNA Derived Amino Acids N-Compounds Amino Acid Plasma Testing Low Levels High Levels Post Prandial Amino Acid Urine Testing Benefits and Limitations Cofactor Indicators Reference Ranges and Examples Branched Chain Amino Acids (BCAA) Histidine Sarcosine b-Amino Acids Taurine b-Alanine g-Aminobutyrate (GABA) Carnosine Anserine Catecholamine Synthesis Hydroxyproline Clinical Tips I. Introduction to Organic Acids Functions of Organic Acids and Clinical Presentations Organic Acid Analysis - Features Clinical Relevance Fatty Acid Metabolism Carbohydrate Metabolism Citric Acid Cycle Central Energy Pathways Dicarboxylic Aciduria Ketone Body Production Energy Production and Enzyme Cofactors Lactate Pyruvate Elevated TCA Intermediated Cytochrome c oxidase deficiency Coenzyme Q10 deficiency Amino Acid Pathways a-Ketoisovalerate, a-Ketoisocaproate and a-Keto-b-methylvalerate, Methylmalonate, b-Hydroxyisovalerate, Hydroxymethylglutarate Branched Chain Keto Acids a-Ketoisovalerate - Valine a-Ketoisocaproate - Leucine a-Keto-b-methylvalerate - Isoleucine B12 and Folate Differential Assessment Multiple Carboxylase Deficiency Biotin Deficiency Cholesterol Synthesis B-Complex Markers Deficiencies due to Dysbiosis Tryptophan Metabolism Catecholamine Synthesis Neurotransmitters Detoxification Markers Glucuronidation Ammonia Detoxification Lipid Peroxidation and Cell-Growth Regulation p-Hydroxyphenylacetate Toxic Solvent Exposure 2-Methylhippurate and xylene intoxication Amino Acid Re-uptake impairment Sulfation Detoxification Markers - Summary Intestinal Dysbiosis Markers Bacterial Benzoate, Hippurate, Phenylacetate, Phenylproprionate, p-Cresol, p-Hydroxybenzoate, P-Hydroxyphenylacetate, Tricarballylate Clostridial Dihydroxyphenylproprionate (DHPP) Yeast/Fungal Tartarate, Citramalate, b-Ketoglutarate, Arabinose Benzoate Phenylacetate p-Cresol, p-Hydroxybenzoate, P-Hydroxyphenylacetate Tricarballylate Dihydroxyphenylproprionate (DHPP) Tartarate, Citramalate, b-Ketoglutarate, Arabinose J. Fatty Acid Analysis Applications Concentration versus Percentage Applications Developmental disorders Heart Disease Cancer risk management Neurological disorders Immune modulation disorders Fatty Acid Assessments Deficiencies and imbalances Functional needs for vitamins and minerals RBC versus Plasma RBC - long-term tissue balance Plasma - quality of FA available for rapid mobilization Inhibition of Fatty Acid Oxidation Elongation of Fatty Acids Fatty Acid Synthesis Carnitine Oxidative Energy Metabolism K. Assessing Thyroid Function Disease Prevalence and Relational Functions Symptoms Hypo or Hyper Customary Dx TSH "Alternative" Dx TSH Rx Supplementation Levothyroixin Liothyroxine Liotrix Natural Natural Supplementation Armour Westhroid Naturethroid Diagnostic Failure Treatment Failure Risk Factors Xenobiotics Chlorine/fluoride, Mercury, Perchlorate, MTBE Implicated Illnesses Fibromyalgia Carpal tunnel Mitral Valve Prolapse Polycystic Ovary Depression and others Testing Protocol CellMate Amino Acids Organic Acids Thyroid Antibodies reverse T3, Free Hormones, TRH stimulation Interpreting results Thyroid panel values T4, T3 Uptake, T7, TSH, Thyroid antibodies, reverse T3 Functional Dynamics Phenylalanine and Tyrosine Iodine Selenium Peripheral conversion reverse T3 suppression Thyroid Assessment Meds Interactions Liver and Steroid Metabolism Androgens Hormone Transport Peripheral Metabolism Euthyroid Sick Syndrome Reduced by: Carbohydrate restriction Chronic illness Hypothyroidism High Stress Functional Support Diet Amino Acids Cofactors Proper selection of meds Hormone Balance Balance Charting Proper TSH Range Saliva Screening L. Assessing Cardiovascular Function Risk Markers and Differential Assessment Basic Chemistry Risk Markers Amino Acid in Plasma Risk Markers Organic Acids in Urine Risk Markers Differential Assessment Folate, B12, B6 - When and why Does Iron Supplementation Increase the Risk of Cardiovascular Disease? Cardiovascular Assessment HDL cholesterol, Direct LDL cholesterol, Lipoprotein (a), Coenzyme Q10, Triglycerides, Lipid Peroxides, Apolipoprotein A-1, Apolipoprotein B, Homocysteine, C-Reactive Protein, Fibrinogen, RBC Magnesium, Insulin, Vitamin E, Testosterone, (males), Apo B/A-1 Ratio M. Addressing GI Function In progress N. Liver Detoxification In progress O. Glucose Regulation Dysglycemia Glucose Regulation Fasting glucose 2-hour post-challenge glucose Insulin levels Hemoglobin A1c IGF-1 Fructosamine as a marker of short-term glycemic control Hormonal Imbalances of DHEA, cortisol and IGF-1 P. Element Analysis Macro- and Micro-Essentials Trace Elements Toxic Elements Metal Toxicity Intervention Metal Toxicity Detoxification Metal Toxicity Challenge Testing DMSA EDTA DMPS Penicillamine Metal Toxicity Cholesterol Q. Pre-Chelation Assessment Critical Assessment IV-C Heavy Metal Protocol Pre-Chelation Assessment Critical Assessments Kidney pathology screening Creatinine Clearance Glucose-6-phosphate dehydrogenase Hemorrhagic disorder screening Major Functions of the Kidney Routine Biochemical Assessment of Kidney Function Hemorrhagic Disorders Vascular Disorders Allergic Purpura Hemorrhagic Telangiectasia Misc. Vascular Purpuras Platelet Disorders Hereditary Coagulation Disorders Vitamin K Deficiencies Disseminated Intravascular Coagulation IV-C contraindications Moderate risk IV-C candidates IV-C Risk Assessment IV-C Effect on Chemistry Baseline test before high dose Vitamin C Pre-Chelation Assessment Heavy Metal Chelation Protocols R. Allergy Screening Allergenic Substances, Allergy Responses, Immunity/Membranes/Boundaries Definition of Allergy Symptoms of Food Intolerance Food Intolerance Allergy Response Mechanisms IgE, IgA, IgM, IgG - subclasses 1&4, Immune Complexes, Platelet Aggregation, Leukocytes Allergy Screening Barriers for Preservation of Self - Immune Function Dynamic Balance Amino Acids, Vitamins and Minerals, Fatty Acids, Light, Love, Rhythm Minimizing Exposure Identify allergens GAME, ALCAT®, Challenge Re-establish or reinforce boundaries Biochemical Balance Adrenal, Thyroid, other Hormones Digestive Impairment Conditions resulting in increased allergic response Testing CWP, Amino Acids, Organic Acids, IgG 1&4, ALCAT®, Adrenal Stress Profile, Dysbiosis Markers, RBC Fatty Acids, Secretory IgA, Antibody studies Detoxification Penicillamine, Desferol, DMPS, DMSA, EDTA, NAC, Fasting/Diet modification, Fiber and probiotics, Colonics/detox baths, Niacin/sauna therapy, Oligoantigenic diet (protein hydrolysates), Liver detoxification S. Hormones Metabolism of Steroids T. Infection: Antibiotics and Alternatives "I'll ask my doctor about it" "Medical errors kill almost 100,000 Americans annually" Nutritional Education in Medical Training "Let food be your medicine and medicine be your food" "Let you food be refined and let your medicine be manufactured drugs" So what are we to do? Basic tenets of allopathic medicine Pasteur versus Beauchamp Antibiotics Allergic reactions associated with antibiotics Nutritional influences on infection and immunity Infection and nutritional status Nutrition status and drug nutrient depletion Health Maintenance Dietary Recommendations Nutritional Supplementation Healthy Support How do I know what to take? U. Xenobiotics Xylene V. Autism Protocols for testing W. Questions and Answers X. Diets 14 Day High Protein Diet Y. CellMate Wellness Systems Reports and Tests What are CellMate™ Reports? Getting Started with CellMate™ Reports 3RPlus+™ - The Future of Interpretive Reporting Ordering a CellMate™ Report Information Questionnaire and Order Form Direct Laboratory Services HCP Registration DLS Instructions CellMate™ Reports as a Practice Builder Z. References Recommended Reading List General References Drug Interactions Clinical Correlations Nutrition References Laboratory References

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