ApoE Genetic Testing now Available from Carbon Based
Date 2005/7/21 17:23:11 | Topic: Company News
| Genetic testing is a controversial, valuable, yet poorly interpreted clinical tool. Carbon Based, after consulting with its medical advisory, is making this tool available to its clinicians for the first time with the release of our first genetic test offering, Apolipoprotein E.
The most common use for this test is as a risk assessment for both the development of cardiovascular disease and Alzheimer’s. We at Carbon Based are interested in another aspect of the test as a potential marker for an individual’s ability to detoxify mercury and other heavy metals naturally. It is our opinion that this is where the value in the test lies.
The following is a quick interpretive guide to the 5 possible gene allele pairings that make up ApoE. A cautionary comment needs to be added here as we are talking about possibilities and probabilities, not definitive outcomes. Since genetic research is in its infancy, much is still unknown regarding other factors like diet, environment or other genetic traits.
Information Sheet for Apolipoprotein E
ApoE 2 2 – This is the best case scenario. People with this gene allele pairing seemingly have the best possible ability to detoxify heavy metals, especially mercury. On a scale of 1-5 the risk factor is a #1. The risk for cardiovascular disease and Alzheimer’s disease is lower than any other group not taking into account dietary, behavioral or environmental causes. This gene allele contains the following pairings:
Cysteine/Cysteine Cysteine/Cysteine
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ApoE 2 3 –This allele pairing suggests a good ability to detoxify heavy metals, especially mercury. On a scale of 1-5 the risk factor is a #2. This gene allele contains the following pairings:
Cysteine/Cysteine Cysteine/Arginine
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ApoE 3 3 - This is the most common of the possibilities of this allele pairing. This is suggests that this individual is somewhat impaired in their ability to detoxify mercury but still has some capacity. On a scale of 1-5 the risk factor is a #3. This genotype, while it does not provide protection against the development of cardiovascular disease or Alzheimer’s, it does not seem to affect the progression of the two disorders. This gene allele contains the following pairings:
Cysteine/Arginine Cysteine/Arginine
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ApoE 3 4 – This allele pairing suggests that the individual has a substantial inability to detoxify mercury. On a scale of 1-5 the risk factor is a #4. A person with this result may want to consider a more aggressive form of heavy metal avoidance and/or removal. This gene allele contains the following pairings:
Cysteine/Arginine Arginine/Arginine
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ApoE 4 4– In terms of the ability to detoxify mercury, this is the worst case scenario when it comes to the ability to detoxify mercury. The risk for developing cardiovascular disease and Alzheimer’s is the highest of all. A person with this result may want to consider a more aggressive form of heavy metal avoidance and/or removal. On a scale of 1-5 the risk factor is a #5. This gene allele contains the following pairings:
Arginine/Arginine Arginine/Arginine
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These statements have not been evaluated by the Food and Drug Administration. These statements are not intended to diagnose, treat, cure or prevent any disease.
The test can either use blood or a simple buccal swab (scrapings from the cheeks). If you are interested in this test, please call our offices at 775-851-3337. This test must be done through a licensed health care practitioner.
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